Interleukin-6
Inflammation markersA pro-inflammatory cytokine that signals active tissue inflammation.
This is information about your result, not a diagnosis. Your provider can tell you what it means for you.
What is Interleukin-6?
Interleukin-6 (IL-6) is a cytokine, a signaling protein the immune system produces in response to infection or tissue damage. A high level in the mouth is a sign the immune system is responding to something, often bacteria.
Why it matters
IL-6 is part of the body's inflammation response. Inflammation that goes on for a long time is associated with gum and bone damage. A high level in saliva is associated with gum inflammation, and researchers have linked it to inflammation elsewhere in the body.
What a high result can mean
A high IL-6 is associated with active inflammation in the gums. That may reflect bacteria, an injury, or a strong immune response. Seen alongside high bacteria levels, it is often a sign of active gum disease; only your dentist can confirm that.
What usually happens next
Your dentist will look for the cause, which is often bacteria. Treatment that reduces the bacteria is often followed by a lower IL-6, and a repeat test can show whether it has.
Related markers
Interleukin-1 beta
A key inflammatory mediator that triggers bone resorption in periodontal disease.
High-sensitivity C-reactive protein
A systemic inflammation marker that links oral health to overall health.
Porphyromonas gingivalis
A key “red complex” bacterium strongly linked to severe periodontal disease.
This page explains what the test measures. It is not a diagnosis, and it cannot tell you what your result means for you. Your provider can.